Topic

Longevity and metabolic compounds.

NAD+ and its precursors, rapamycin, metformin, the mitochondrial peptides and the senolytics — the compounds taken for a result that is measured in decades.

The defining problem of this category is that the outcome is unobservable on any timescale you can track. What you can track are the markers people use as proxies: fasting glucose and HbA1c, lipids, ApoB, hsCRP, and the biomarker panels that feed a biological-age estimate. Those move on a scale of months, which makes a consistent lab cadence more valuable here than anywhere else in the library.

All 19 compounds in this topic

Guides for this topic

Run the numbers

Common questions

What markers are worth repeating?

The metabolic panel most of this category is aimed at: fasting glucose, HbA1c, a full lipid panel with ApoB, and hsCRP. Repeat them on a fixed interval rather than when you feel like it, because the interval is what makes the trend readable.

What is a biological age estimate?

A model that maps a set of lab markers plus your chronological age onto an estimated physiological one. BioHack Track computes PhenoAge once you have logged a draw carrying the needed markers. It is a research model, not a diagnosis.

Are these approved for longevity?

Essentially none of them. Several — metformin, rapamycin — are approved medicines for entirely different indications, and their use here is off-label. The compound pages distinguish the two cases explicitly.

Every figure on these pages is sourced the same way — see the editorial policy for the hierarchy, and the full library for all 208 compounds.

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