Fat-soluble vitamin essential for calcium absorption, bone health, and immune function; a very common deficiency, especially with limited sun exposure.
~2-3 weeks (storage form in fat tissue extends effective duration)
Common dose range
1,000-5,000 IU/day, titrated to bloodwork
Typical cycle length
Ongoing, retest levels every 3-6 months
BioHack Track models Vitamin D3 (Cholecalciferol) at a half-life of 360 hours, so every dose you log is decayed against that curve and the app shows estimated active levels — not just what you typed.
No approved product cited
No FDA-approved product for this compound is cited on this page, and no approved human dose is quoted. Treat the range below as research and community practice rather than a prescribed dose.
Reconstitution
Oral softgel, tablet, or liquid drops; no reconstitution needed.
Storage
Store at room temperature, away from light.
Cautions
Fat-soluble and can accumulate — very high doses over time can cause hypercalcemia. Test blood levels rather than guessing.
Track Vitamin D3 (Cholecalciferol) in BioHack Track. Half-life, dose range and route come
pre-filled from this library — log a dose and the app counts your vial down, models what is
in your system, and puts it on the same chart as your labs and body composition.
Evidence Check asks 10 questions about every compound. For Vitamin D3 (Cholecalciferol) it can answer 3 of them, from the papers we hold — graded by how strong the study design is, not by whether the findings are flattering. These are the same verdicts the app gives.
Strongest EvidenceBone density
Meta-analyses or systematic reviews exist — the highest grade of evidence there is, whatever they conclude. Read them.
What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta-analysisMeta-Analysis · Int J Older People Nurs · 2023 · PMID 35842938
Clinical characteristics associated with bone mineral density improvement after 1-year alendronate/vitamin d3 or calcitriol treatment: Exploratory results from a phase 3, randomized, controlled trial on postmenopausal osteoporotic women in ChinaRandomized Controlled Trial · Medicine (Baltimore) · 2018 · PMID 30075569
Bone loss after heart transplant: effect of alendronate, etidronate, calcitonin, and calcium plus vitamin D3Randomized Controlled Trial · Prog Transplant · 2012 · PMID 22951500
Strongest EvidenceInflammation
Meta-analyses or systematic reviews exist — the highest grade of evidence there is, whatever they conclude. Read them.
Effect of Vitamin D3 Supplementation on Inflammatory Markers and Glycemic Measures among Overweight or Obese Adults: A Systematic Review of Randomized Controlled TrialsSystematic Review · PLoS One · 2016 · PMID 27116227
Strongest EvidenceWeight loss
Meta-analyses or systematic reviews exist — the highest grade of evidence there is, whatever they conclude. Read them.
Effect of Vitamin D3 Supplementation on Inflammatory Markers and Glycemic Measures among Overweight or Obese Adults: A Systematic Review of Randomized Controlled TrialsSystematic Review · PLoS One · 2016 · PMID 27116227
Research references only. Not medical advice, and not a recommendation to take anything.
Look up the research
These open a search of each database for Vitamin D3 (Cholecalciferol) — they are not citations, and nothing here is evidence for any particular dose. The same links are in the app.
11 papers naming Vitamin D3 (Cholecalciferol) in the title, drawn from PubMed and limited to reviews, meta-analyses and trials. Each was checked against PubMed’s own record for its title, journal and year. This is a starting point, not an evidence review — nothing here is offered as support for the dose range above, and the list is not exhaustive. See the editorial policy.
The half-life, route and dose range on this page are compiled from published
pharmacokinetic literature, manufacturer and product monographs where one exists, and the
ranges commonly reported in clinical and research use. They are kept as a range
rather than a single figure because that is what the sources actually support — a
half-life varies with route, formulation and the person.
These are not citations, and this page is not a review of the evidence. Where a
number matters to you, follow the database links above and read the source. We say so
plainly rather than dressing a compiled reference up as one.
Nothing on this page has been reviewed by a named clinician. It is a reference for
people already tracking a protocol, not a recommendation to start one.
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Last updated ·
Corrections: support
General reference compiled for use
inside the app, not medical advice and not a recommendation to take anything. Dose ranges are
what is commonly discussed, not a prescription. Talk to a qualified healthcare professional.