Compound library / GLP-1s & weight loss / Fat Loss / Metabolic

Setmelanotide (Imcivree)

FDA-approved melanocortin-4 receptor agonist, but only for chronic weight management in specific rare genetic obesity conditions (POMC, PCSK1, or LEPR deficiency).

CategoryFat Loss / Metabolic
Regulatory standingNo approved product cited
Typical routeSubcutaneous
Half-life~11 days
Common dose rangePer FDA label, titrated; not intended for general weight loss
Typical cycle lengthOngoing under specialist medical supervision

BioHack Track models Setmelanotide (Imcivree) at a half-life of 264 hours, so every dose you log is decayed against that curve and the app shows estimated active levels — not just what you typed.

No approved product cited

No FDA-approved product for this compound is cited on this page, and no approved human dose is quoted. Treat the range below as research and community practice rather than a prescribed dose.

Reconstitution

Supplied pre-filled by pharmacy.

Storage

Refrigerate; do not freeze.

Cautions

FDA-approved only for specific diagnosed genetic conditions confirmed by genetic testing — not a general-purpose weight-loss drug despite grey-market interest.

Track Setmelanotide (Imcivree) in BioHack Track. Half-life, dose range and route come pre-filled from this library — log a dose and the app counts your vial down, models what is in your system, and puts it on the same chart as your labs and body composition.

Others in Fat Loss / Metabolic

What the evidence says

Evidence Check asks 10 questions about every compound. For Setmelanotide (Imcivree) it can answer 1 of them, from the papers we hold — graded by how strong the study design is, not by whether the findings are flattering. These are the same verdicts the app gives.

Strongest EvidenceWeight loss

Meta-analyses or systematic reviews exist — the highest grade of evidence there is, whatever they conclude. Read them.

  • Adverse event profile of setmelanotide in obesity: an integrated assessment and systematic review using disproportionality analysis, case reports and meta-analysisMeta-Analysis · Expert Opin Drug Saf · 2026 · PMID 39924461
  • Setmelanotide for the Treatment of Acquired Hypothalamic ObesityRandomized Controlled Trial · N Engl J Med · 2026 · PMID 42418774
  • Setmelanotide for the treatment of acquired hypothalamic obesity: a phase 2, open-label, multicentre trialStudy · Lancet Diabetes Endocrinol · 2024 · PMID 38697184

Look up the research

These open a search of each database for Setmelanotide (Imcivree) — they are not citations, and nothing here is evidence for any particular dose. The same links are in the app.

Work it out

Selected published studies

9 papers naming Setmelanotide (Imcivree) in the title, drawn from PubMed and limited to reviews, meta-analyses and trials. Each was checked against PubMed’s own record for its title, journal and year. This is a starting point, not an evidence review — nothing here is offered as support for the dose range above, and the list is not exhaustive. See the editorial policy.

Where these figures come from

The half-life, route and dose range on this page are compiled from published pharmacokinetic literature, manufacturer and product monographs where one exists, and the ranges commonly reported in clinical and research use. They are kept as a range rather than a single figure because that is what the sources actually support — a half-life varies with route, formulation and the person.

These are not citations, and this page is not a review of the evidence. Where a number matters to you, follow the database links above and read the source. We say so plainly rather than dressing a compiled reference up as one.

Nothing on this page has been reviewed by a named clinician. It is a reference for people already tracking a protocol, not a recommendation to start one.

Published by Creative Images LLC · Last updated · Corrections: support