Compound library / GLP-1s & weight loss / Fat Loss / GLP-1

Semaglutide

GLP-1 receptor agonist, FDA-approved (Ozempic/Wegovy) for type 2 diabetes and chronic weight management.

CategoryFat Loss / GLP-1
Regulatory standingApproved medicine
Typical routeSubcutaneous
Half-life~1 week
Common dose range0.25-2.4 mg/week, titrated
Typical cycle lengthOngoing under medical supervision

BioHack Track models Semaglutide at a half-life of 168 hours, so every dose you log is decayed against that curve and the app shows estimated active levels — not just what you typed.

Approved medicine

An FDA-approved product containing this compound exists, and its label is linked under Primary sources below. That label is the authority on dosing; the range on this page describes what people commonly track, including off-label use, and does not replace it.

Reconstitution

Typically supplied pre-filled; compounded versions require reconstitution per pharmacy instructions.

Storage

Refrigerate; some pens stable at room temp short-term per label.

Cautions

Prescription medication — requires medical supervision. GI side effects common; contraindicated with personal/family history of medullary thyroid carcinoma.

Track Semaglutide in BioHack Track. Half-life, dose range and route come pre-filled from this library — log a dose and the app counts your vial down, models what is in your system, and puts it on the same chart as your labs and body composition.

Others in Fat Loss / GLP-1

What the evidence says

Evidence Check asks 10 questions about every compound. For Semaglutide it can answer 1 of them, from the papers we hold — graded by how strong the study design is, not by whether the findings are flattering. These are the same verdicts the app gives.

Strongest EvidenceWeight loss

Meta-analyses or systematic reviews exist — the highest grade of evidence there is, whatever they conclude. Read them.

  • Long-Term Efficacy and Safety of Once-Weekly Semaglutide for Weight Loss in Patients Without Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsMeta-Analysis · Am J Cardiol · 2024 · PMID 38679221
  • Assessment of Thyroid Carcinogenic Risk and Safety Profile of GLP1-RA Semaglutide (Ozempic) Therapy for Diabetes Mellitus and Obesity: A Systematic Literature ReviewSystematic Review · Int J Mol Sci · 2024 · PMID 38673931
  • Oral Semaglutide at a Dose of 25 mg in Adults with Overweight or ObesityRandomized Controlled Trial · N Engl J Med · 2025 · PMID 40934115

Look up the research

These open a search of each database for Semaglutide — they are not citations, and nothing here is evidence for any particular dose. The same links are in the app.

Work it out

Selected published studies

12 papers naming Semaglutide in the title, drawn from PubMed and limited to reviews, meta-analyses and trials. Each was checked against PubMed’s own record for its title, journal and year. This is a starting point, not an evidence review — nothing here is offered as support for the dose range above, and the list is not exhaustive. See the editorial policy.

Where these figures come from

The half-life, route and dose range on this page are compiled from published pharmacokinetic literature, manufacturer and product monographs where one exists, and the ranges commonly reported in clinical and research use. They are kept as a range rather than a single figure because that is what the sources actually support — a half-life varies with route, formulation and the person.

These are not citations, and this page is not a review of the evidence. Where a number matters to you, follow the database links above and read the source. We say so plainly rather than dressing a compiled reference up as one.

Nothing on this page has been reviewed by a named clinician. It is a reference for people already tracking a protocol, not a recommendation to start one.

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