Compound library / Cognitive & nootropics / Cognitive / Nootropic

Salidroside

Primary bioactive glycoside from Rhodiola rosea (rose root), explored for adaptogenic, anti-fatigue, neuroprotective, and anti-depressant-like effects. Often studied alongside rosavin (the other major Rhodiola compound).

CategoryCognitive / Nootropic
Regulatory standingNo approved product cited
Typical routeOral
Half-life~1-3 hours
Common dose range50-500 mg/day of a standardized Rhodiola extract (containing ~1-3% salidroside), or 15-30 mg isolated salidroside
Typical cycle length4-8 weeks on / 2-week break

BioHack Track models Salidroside at a half-life of 2 hours, so every dose you log is decayed against that curve and the app shows estimated active levels — not just what you typed.

No approved product cited

No FDA-approved product for this compound is cited on this page, and no approved human dose is quoted. Treat the range below as research and community practice rather than a prescribed dose.

Reconstitution

Oral capsule or extract; no reconstitution needed.

Storage

Store at room temperature.

Cautions

Generally well tolerated; may interact with MAOIs or psychostimulants. Some people experience insomnia if taken late in the day.

Track Salidroside in BioHack Track. Half-life, dose range and route come pre-filled from this library — log a dose and the app counts your vial down, models what is in your system, and puts it on the same chart as your labs and body composition.

Others in Cognitive / Nootropic

What the evidence says

Evidence Check asks 10 questions about every compound. For Salidroside it can answer 3 of them, from the papers we hold — graded by how strong the study design is, not by whether the findings are flattering. These are the same verdicts the app gives.

Strongest EvidenceCognition

Meta-analyses or systematic reviews exist — the highest grade of evidence there is, whatever they conclude. Read them.

  • Neuroprotective Mechanisms of Salidroside in Alzheimer's Disease: A Systematic Review and Meta-analysis of Preclinical StudiesMeta-Analysis · J Agric Food Chem · 2023 · PMID 37934032
  • Salidroside as a potential neuroprotective agent for ischemic stroke: a review of sources, pharmacokinetics, mechanism and safetyReview · Biomed Pharmacother · 2020 · PMID 32603893
Strongest EvidenceInflammation

Meta-analyses or systematic reviews exist — the highest grade of evidence there is, whatever they conclude. Read them.

  • Anti-inflammatory and antioxidant effects of salidroside in diabetic nephropathy: a systematic review and meta-analysis of preclinical studiesMeta-Analysis · Front Pharmacol · 2026 · PMID 42038298
  • Protective effects of salidroside on NAFLD rodent models by alleviating oxidative stress and inflammation: a meta-analysis and mechanism explorationMeta-Analysis · Front Pharmacol · 2026 · PMID 42028434
Some Clinical EvidenceWound healing

Clinical trials in humans have looked at this.

  • Salidroside and exercise performance in healthy active young adults - an exploratory, randomized, double-blind, placebo-controlled studyRandomized Controlled Trial · J Int Soc Sports Nutr · 2024 · PMID 39601362

Look up the research

These open a search of each database for Salidroside — they are not citations, and nothing here is evidence for any particular dose. The same links are in the app.

Work it out

Selected published studies

10 papers naming Salidroside in the title, drawn from PubMed and limited to reviews, meta-analyses and trials. Each was checked against PubMed’s own record for its title, journal and year. This is a starting point, not an evidence review — nothing here is offered as support for the dose range above, and the list is not exhaustive. See the editorial policy.

Where these figures come from

The half-life, route and dose range on this page are compiled from published pharmacokinetic literature, manufacturer and product monographs where one exists, and the ranges commonly reported in clinical and research use. They are kept as a range rather than a single figure because that is what the sources actually support — a half-life varies with route, formulation and the person.

These are not citations, and this page is not a review of the evidence. Where a number matters to you, follow the database links above and read the source. We say so plainly rather than dressing a compiled reference up as one.

Nothing on this page has been reviewed by a named clinician. It is a reference for people already tracking a protocol, not a recommendation to start one.

Published by Creative Images LLC · Last updated · Corrections: support