Compound library / Cognitive / Nootropic

NSI-189 (Phosphate)

Benzylpiperazino-aminopyridine compound originally developed by Neuralstem that promotes hippocampal neurogenesis in vitro; explored for depression and cognitive enhancement. Phase 2 trials for MDD showed mixed results.

CategoryCognitive / Nootropic
Typical routeOral
Half-lifeNot well characterized in humans
Common dose range40-80 mg/day in published trials
Typical cycle length8-12 weeks

BioHack Track models NSI-189 (Phosphate) at a half-life of 4 hours, so every dose you log is decayed against that curve and the app shows what is still circulating — not just what you typed.

Reconstitution

Typically supplied as capsules or powder; no reconstitution needed.

Storage

Store at room temperature, away from light.

Cautions

Not FDA-approved. Phase 2 data was mixed; not a proven antidepressant. Long-term effects on hippocampal growth in humans are not established.

Track NSI-189 (Phosphate) in BioHack Track. Half-life, dose range and route come pre-filled from this library — log a dose and the app counts your vial down, models what is in your system, and puts it on the same chart as your labs and body composition.

Others in Cognitive / Nootropic

Look up the research

These open a search of each database for NSI-189 (Phosphate) — they are not citations, and nothing here is evidence for any particular dose. The same links are in the app.

Work it out