Compound library / Cognitive / Anxiolytic

PE-22-28 (Mini-Spadin)

Small peptide that blocks TREK-1 potassium channels, studied in animal models as a fast-acting antidepressant candidate (a more stable derivative of the original Spadin peptide).

CategoryCognitive / Anxiolytic
Typical routeSubcutaneous
Half-lifeDesigned to be more stable than Spadin, but human half-life not established
Common dose rangeResearch-stage only — no established human dosing
Typical cycle lengthNot established

BioHack Track models PE-22-28 (Mini-Spadin) at a half-life of 1 hours, so every dose you log is decayed against that curve and the app shows what is still circulating — not just what you typed.

Reconstitution

Reconstitute with bacteriostatic water.

Storage

Refrigerate after reconstitution.

Cautions

Animal-study compound only; has not been tested in human depression trials as of this writing.

Track PE-22-28 (Mini-Spadin) in BioHack Track. Half-life, dose range and route come pre-filled from this library — log a dose and the app counts your vial down, models what is in your system, and puts it on the same chart as your labs and body composition.

Others in Cognitive / Anxiolytic

Look up the research

These open a search of each database for PE-22-28 (Mini-Spadin) — they are not citations, and nothing here is evidence for any particular dose. The same links are in the app.

Work it out