Compound library / Healing & recovery / Healing / Recovery

PDRN (Polydeoxyribonucleotide)

DNA-derived compound extracted from salmon sperm that activates adenosine A2A receptors to promote tissue regeneration, collagen synthesis, and anti-inflammatory signaling; used clinically in some countries for wound healing and orthopedic applications.

CategoryHealing / Recovery
Regulatory standingNo approved product cited
Typical routeSubcutaneous
Half-life~1-2 hours
Common dose range3-5.625 mg (1 ampoule), 3x/week or as directed by protocol
Typical cycle length4-8 weeks

BioHack Track models PDRN (Polydeoxyribonucleotide) at a half-life of 1.5 hours, so every dose you log is decayed against that curve and the app shows estimated active levels — not just what you typed.

No approved product cited

No FDA-approved product for this compound is cited on this page, and no approved human dose is quoted. Treat the range below as research and community practice rather than a prescribed dose.

Reconstitution

Often supplied as pre-mixed ampoules (e.g. Placentex); some lyophilized forms require reconstitution with saline.

Storage

Refrigerate; protect from light.

Cautions

Approved in South Korea and some EU countries for dermal use; not FDA-approved. Grey-market injectable sourcing carries the usual purity/sterility concerns.

Track PDRN (Polydeoxyribonucleotide) in BioHack Track. Half-life, dose range and route come pre-filled from this library — log a dose and the app counts your vial down, models what is in your system, and puts it on the same chart as your labs and body composition.

Others in Healing / Recovery

What the evidence says

Evidence Check asks 10 questions about every compound. For PDRN (Polydeoxyribonucleotide) it can answer 2 of them, from the papers we hold — graded by how strong the study design is, not by whether the findings are flattering. These are the same verdicts the app gives.

Some Clinical EvidenceSkin & collagen

Clinical trials in humans have looked at this.

  • Clinical evaluation of the trophic effect of polydeoxyribonucleotide (PDRN) in patients undergoing skin explants. A Pilot StudyRandomized Controlled Trial · Curr Med Res Opin · 2001 · PMID 11759182
Insufficient EvidenceWound healing

Only reviews or early work — not enough to say either way.

  • Polydeoxyribonucleotide (PDRN): a safe approach to induce therapeutic angiogenesis in peripheral artery occlusive disease and in diabetic foot ulcersReview · Cardiovasc Hematol Agents Med Chem · 2009 · PMID 19860658

Look up the research

These open a search of each database for PDRN (Polydeoxyribonucleotide) — they are not citations, and nothing here is evidence for any particular dose. The same links are in the app.

Work it out

Selected published studies

8 papers naming PDRN (Polydeoxyribonucleotide) in the title, drawn from PubMed and limited to reviews, meta-analyses and trials. Each was checked against PubMed’s own record for its title, journal and year. This is a starting point, not an evidence review — nothing here is offered as support for the dose range above, and the list is not exhaustive. See the editorial policy.

Where these figures come from

The half-life, route and dose range on this page are compiled from published pharmacokinetic literature, manufacturer and product monographs where one exists, and the ranges commonly reported in clinical and research use. They are kept as a range rather than a single figure because that is what the sources actually support — a half-life varies with route, formulation and the person.

These are not citations, and this page is not a review of the evidence. Where a number matters to you, follow the database links above and read the source. We say so plainly rather than dressing a compiled reference up as one.

Nothing on this page has been reviewed by a named clinician. It is a reference for people already tracking a protocol, not a recommendation to start one.

Published by Creative Images LLC · Last updated · Corrections: support