Compound library / Growth hormone & muscle / Growth Hormone Secretagogue

MK-677 (Ibutamoren)

Oral ghrelin-receptor agonist (not a peptide, but commonly tracked alongside GH secretagogues) that raises GH and IGF-1 levels.

CategoryGrowth Hormone Secretagogue
Regulatory standingNo approved product cited
Typical routeOral
Half-life~24 hours
Common dose range10-25 mg/day
Typical cycle length8-12 weeks

BioHack Track models MK-677 (Ibutamoren) at a half-life of 24 hours, so every dose you log is decayed against that curve and the app shows estimated active levels — not just what you typed.

No approved product cited

No FDA-approved product for this compound is cited on this page, and no approved human dose is quoted. Treat the range below as research and community practice rather than a prescribed dose.

Reconstitution

Typically supplied as capsules or solution; no reconstitution needed.

Storage

Store at room temperature, away from light.

Cautions

Can increase appetite and water retention; monitor blood glucose with prolonged use.

Track MK-677 (Ibutamoren) in BioHack Track. Half-life, dose range and route come pre-filled from this library — log a dose and the app counts your vial down, models what is in your system, and puts it on the same chart as your labs and body composition.

Others in Growth Hormone Secretagogue

What the evidence says

Evidence Check asks 10 questions about every compound. For MK-677 (Ibutamoren) it can answer 4 of them, from the papers we hold — graded by how strong the study design is, not by whether the findings are flattering. These are the same verdicts the app gives.

Some Clinical EvidenceBone density

Clinical trials in humans have looked at this.

  • MK-0677 (ibutamoren mesylate) for the treatment of patients recovering from hip fracture: a multicenter, randomized, placebo-controlled phase IIb studyRandomized Controlled Trial · Arch Gerontol Geriatr · 2011 · PMID 21067829
  • Effect of alendronate and MK-677 (a growth hormone secretagogue), individually and in combination, on markers of bone turnover and bone mineral density in postmenopausal osteoporotic womenRandomized Controlled Trial · J Clin Endocrinol Metab · 2001 · PMID 11238495
  • Oral administration of the growth hormone secretagogue MK-677 increases markers of bone turnover in healthy and functionally impaired elderly adults. The MK-677 Study GroupRandomized Controlled Trial · J Bone Miner Res · 1999 · PMID 10404019
Some Clinical EvidenceSleep

Clinical trials in humans have looked at this.

  • Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in manClinical Trial · Neuroendocrinology · 1997 · PMID 9349662
Some Clinical EvidenceWeight loss

Clinical trials in humans have looked at this.

  • Treatment of obese subjects with the oral growth hormone secretagogue MK-677 affects serum concentrations of several lipoproteins, but not lipoprotein(a)Randomized Controlled Trial · J Clin Endocrinol Metab · 1999 · PMID 10372705
Some Clinical EvidenceWound healing

Clinical trials in humans have looked at this.

  • Oral administration of the growth hormone secretagogue MK-677 increases markers of bone turnover in healthy and functionally impaired elderly adults. The MK-677 Study GroupRandomized Controlled Trial · J Bone Miner Res · 1999 · PMID 10404019
  • Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjectsRandomized Controlled Trial · J Clin Endocrinol Metab · 1996 · PMID 8954023

Look up the research

These open a search of each database for MK-677 (Ibutamoren) — they are not citations, and nothing here is evidence for any particular dose. The same links are in the app.

Work it out

Selected published studies

10 papers naming MK-677 (Ibutamoren) in the title, drawn from PubMed and limited to reviews, meta-analyses and trials. Each was checked against PubMed’s own record for its title, journal and year. This is a starting point, not an evidence review — nothing here is offered as support for the dose range above, and the list is not exhaustive. See the editorial policy.

Where these figures come from

The half-life, route and dose range on this page are compiled from published pharmacokinetic literature, manufacturer and product monographs where one exists, and the ranges commonly reported in clinical and research use. They are kept as a range rather than a single figure because that is what the sources actually support — a half-life varies with route, formulation and the person.

These are not citations, and this page is not a review of the evidence. Where a number matters to you, follow the database links above and read the source. We say so plainly rather than dressing a compiled reference up as one.

Nothing on this page has been reviewed by a named clinician. It is a reference for people already tracking a protocol, not a recommendation to start one.

Published by Creative Images LLC · Last updated · Corrections: support