Compound library / Healing & recovery / Bone Health

Abaloparatide (Tymlos)

Synthetic PTHrP(1-34) analogue, FDA-approved for postmenopausal osteoporosis with high fracture risk; explored in biohacking circles for bone remodeling. Acts preferentially on the anabolic arm of the PTH pathway.

CategoryBone Health
Regulatory standingNo approved product cited
Typical routeSubcutaneous
Half-life~1.7 hours
Common dose range80 mcg once daily (approved dose); research use mirrors this
Typical cycle lengthUp to 18 months per FDA label; not recommended beyond 2 years cumulative anabolic therapy

BioHack Track models Abaloparatide (Tymlos) at a half-life of 1.7 hours, so every dose you log is decayed against that curve and the app shows estimated active levels — not just what you typed.

No approved product cited

No FDA-approved product for this compound is cited on this page, and no approved human dose is quoted. Treat the range below as research and community practice rather than a prescribed dose.

Reconstitution

Supplied as a pre-filled pen; no reconstitution needed.

Storage

Refrigerate until first use; pen stable at room temperature for up to 30 days after opening.

Cautions

Prescription medication with a boxed warning for osteosarcoma risk (based on rat data — clinical significance unknown). Should be followed by an antiresorptive agent to preserve gained bone density.

Track Abaloparatide (Tymlos) in BioHack Track. Half-life, dose range and route come pre-filled from this library — log a dose and the app counts your vial down, models what is in your system, and puts it on the same chart as your labs and body composition.

Others in Bone Health

What the evidence says

Evidence Check asks 10 questions about every compound. For Abaloparatide (Tymlos) it can answer 1 of them, from the papers we hold — graded by how strong the study design is, not by whether the findings are flattering. These are the same verdicts the app gives.

Strongest EvidenceBone density

Meta-analyses or systematic reviews exist — the highest grade of evidence there is, whatever they conclude. Read them.

  • The Safety and Efficacy of Abaloparatide on Postmenopausal Osteoporosis: A Systematic Review and Meta-analysisMeta-Analysis · Clin Ther · 2024 · PMID 38307725
  • Effect of a sequential treatment combining abaloparatide and alendronate for the management of postmenopausal osteoporosisRandomized Controlled Trial · Expert Opin Pharmacother · 2018 · PMID 29251010
  • Effect of Abaloparatide vs Placebo on New Vertebral Fractures in Postmenopausal Women With Osteoporosis: A Randomized Clinical TrialRandomized Controlled Trial · JAMA · 2016 · PMID 27533157

Look up the research

These open a search of each database for Abaloparatide (Tymlos) — they are not citations, and nothing here is evidence for any particular dose. The same links are in the app.

Work it out

Selected published studies

6 papers naming Abaloparatide (Tymlos) in the title, drawn from PubMed and limited to reviews, meta-analyses and trials. Each was checked against PubMed’s own record for its title, journal and year. This is a starting point, not an evidence review — nothing here is offered as support for the dose range above, and the list is not exhaustive. See the editorial policy.

Where these figures come from

The half-life, route and dose range on this page are compiled from published pharmacokinetic literature, manufacturer and product monographs where one exists, and the ranges commonly reported in clinical and research use. They are kept as a range rather than a single figure because that is what the sources actually support — a half-life varies with route, formulation and the person.

These are not citations, and this page is not a review of the evidence. Where a number matters to you, follow the database links above and read the source. We say so plainly rather than dressing a compiled reference up as one.

Nothing on this page has been reviewed by a named clinician. It is a reference for people already tracking a protocol, not a recommendation to start one.

Published by Creative Images LLC · Last updated · Corrections: support